The neuromuscular junction of the mouse after black widow spider venom.
نویسندگان
چکیده
منابع مشابه
Reversibility and mode of action of Black Widow spider venom on the vertebrate neuromuscular junction
Black widow spider venom (BWSV) stimulates transmitter release and depletes synaptic vesicles from muscles bathed in a sodium free medium containing 1 mM EGTA. However, frog neuromuscular junctions treated with BWSV in glucosamine Ringer's and post-treated with antivenin recover normal function. This suggests that probably the permanent block of neuromuscular transmission is due to changes in p...
متن کاملEffects of Black Widow Spider Venom and Ca" on Quantal Secretion at the Frog Neuromuscular Junction
A modification of the classical procedure of fluctuation analysis is used to measure the waveform, w(t), mean amplitude, (h), and mean rate of occurrence, (r), of miniature endplate potentials (MEPPs) at frog cutaneous pectoris neuromuscular junctions treated with black widow spider venom (BWSV) . MEPP parameters are determined from the power spectrum of the fluctuating potential and the second...
متن کاملEffects of black widow spider venom and Ca2+ on quantal secretion at the frog neuromuscular junction
A modification of the classical procedure of fluctuation analysis is used to measure the waveform, w(t), mean amplitude, (h), and mean rate of occurrence, (r), of miniature endplate potentials (MEPPs) at frog cutaneous pectoris neuromuscular junctions treated with black widow spider venom (BWSV). MEPP parameters are determined from the power spectrum of the fluctuating potential and the second ...
متن کاملChanges in the Fine Structure of the Neuromuscular Junction of the Frog Caused by Black Widow Spider Venom
Application of black widow spider venom to the neuromuscular junction of the frog causes an increase in the frequency of miniature end-plate potentials (min.e.p.p.) and a reduction in the number of synaptic vesicles in the nerve terminal. Shortly after the increase in min.e.p.p. frequency, the presynaptic membrane of the nerve terminal has either infolded or "lifted." Examination of these infol...
متن کاملEffect of Black Widow Spider Venom on the Lobster Neuromuscular Junctions
The effect of black widow spider venom (BWSV) on the junctions of the lobster nerve-muscle preparation was studied by intracellular recordings. After application of BWSV both excitatory and inhibitory postsynaptic potentials (epsp and ipsp) were augmented then suppressed. The frequency of miniature potentials was markedly increased by BWSV. Summated postsynaptic conductance changes appeared to ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1981
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1981.sp013787